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Liothyronine sodium therapy may potentiate the action of anticoagulants (coumarins and phenindione). Anticonvulsants, such as carbamazepine and phenytoin-enhance the metabolism of thyroid hormones and may displace thyroid hormones from plasma proteins.
Initiation or discontinuation of anticonvulsant therapy may alter liothyronine dose requirements. Phenytoin levels may be increase by liothyronine.
Liothyronine raises blood sugar levels and this may upset the stability of patients receiving antidiabetic agents.
If co-administer with cardiac glycosides, adjustment of dosage of cardiac glycoside may be necessary.
Liothyronine increases receptor sensitivity to catecholamines thus accelerating the response to tricyclic antidepressants; concomitant use may precipitate cardiac arrhythmias. A number of drugs may affect thyroid function tests, and this should be borne in mind when monitoring patients on liothyronine therapy.
The effects of sympathomimetic agents (e.g. adrenaline) are also enhanced.
Liothyronine accelerates metabolism of beta-blockers like propranolol.
Metabolism of liothyronine is accelerate by rifampicin, barbiturates and primidone (may increase requirements for liothyronine in hypothyroidism).
Amiodarone may inhibit the de iodination of thyroxine to tri iodothyronine resulting in a decrease concentration of tri iodothyronine, thereby reducing the effects of thyroid hormones.
Liothyronine Sodium 20 micrograms Powder for Solution for Injection
Read all of this leaflet carefully before you start using this medicine because it contains important information for you
Keep this leaflet. You may need to read it again.
If you have any further questions, ask your doctor, pharmacist or nurse. If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. See section 4.
What is in this leaflet:
1. What Liothyronine Sodium injection is and what it is used for
2. What you need to know before you use Liothyronine Sodium injection
3. How to use Liothyronine Sodium injection
4. Possible side effects
5. How to store Liothyronine Sodium injection
6. Contents of the pack and other information
Do not use Liothyronine Sodium injection if:
Know that you are allergic to Liothyronine Sodium or any of the other ingredients of Liothyronine Sodium injection (see section 6 of this leaflet)
you have a disease involving the heart or blood vessels
An overactive thyroid gland with raised levels of thyroid hormones (thyrotoxicosis).
Please tell your doctor before you are given this injection if any of the above applies to you.
Warnings and Precautions
Talk to your doctor or pharmacist before using Liothyronine Sodium injection if you:
suffer from diabetes. The dosage of your diabetic treatment may need to be altered
have heart failure (e.g. suggested by symptoms like swelling of the ankles, breathlessness etc.) or have high blood pressure
are an elderly patient with history of hypothyroidism (low levels of thyroid hormones)
suffer from disorders of the adrenal gland.
Other medicines and Liothyronine Sodium injection:
Tell your doctor or pharmacist if you are using, have recently used or might use any other medicines.
The effects of these medicines may change, especially if you are taking:
medicines called cardiac glycosides (e.g. digoxin) used to treat heart conditions such as heart failure
insulin and other treatments for diabetes
anticonvulsants (e.g. phenytoin, carbamazepine, primidone) used to prevent fits
anticoagulants (e.g. warfarin, phenindione) used to thin the blood and treat blood clots
tricyclic antidepressants (e.g. sertraline) used to treat depression
barbiturates (e.g. amobarbital) taken to induce sleep
Adrenaline (used to increase heart rate)
Amiodarone (medication used for irregular heart beat)
Rifampicin (treatment of tuberculosis).